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The fact that he could keep all the details straight and compartmentalize these different lives and lies is really amazing.. In January 2016, Macchiarini received an extraordinary double dose of bad press. The operation, performed at one of the worlds most prestigious medical universities, part of the Karolinska Institute in Stockholm, was hailed as revolutionary. The very next day, she got an email from a friend that outlined the Pope's plans to visit South America on Benita and Paolo's wedding day. Cardiothoracic surgeon Matthias Corbascio, one of Macchiarinis former colleagues at KI who first raised questions about the work, describes it as terrible and insane. The court basically gave him a slap on the wrist, says Corbascio, who is now at the University of Copenhagen. About 11 centimeters (4 inches) long, one side curves like a halfpipe, composed of cartilage rings and ligaments. Help News from Science publish trustworthy, high-impact stories about research and the people who shape it. As it was built from Claudias own cells, she didnt need to be on any risky immunosuppressant drugs. According to the Karolinska Institutes timeline of the Macchiarini case, the institute recruited Macchiarini as a visiting professor of regenerative medicine/stem cell biology in 2010, and the associated Karolinska University Hospital gave him a part-time contract as a consultant and surgeon around the same time. He said yeah, so I said Lets go for it., After extracting the donors organs, you go next door and you open up Sonia and you remove the diseased trachea, and there is no going back, Dr. Genden said. Next month, she will turn 57. We have estimated Paolo Macchiarini's net worth , money, salary, income, and assets. But that day is always postponed. At the time, Macchiarini was working at Swedens Karolinska Institute, which awards the Nobel Prize in Physiology or Medicine every year. He opened and cleaned out the donors esophagus, laying it against Ms. Seins esophagus. That meant the donor trachea was accompanied by a blood supply that Dr. Genden connected to Ms. Seins blood vessels. Plus: NYC sixth-grader struck and killed by stray bullet; New Hampshire police search for person of interest in double homicide; Fyre Festival fraudster released early from prison; and manhunt continues for escaped Texas prisoner. By June 2013, when Paolo took Benita to Venice, Italy, for a romantic weekend, she knew she was falling madly in love. Those few patients who are still alive including Castillo have survived in spite of the artificial windpipes they received. Only three are still alive as of September 2020. In 2010, the Italian surgeon was recruited by KIhome of the committee that awards the Nobel Prize in Physiology or Medicine. Ohio The donor was a young man (identifying details are being withheld to protect privacy). "I started thinking that if this man is lying to me at such an egregious level, theres no way hes not doing this in his medical life," she told CrimeFeed. Another was a Russian mother named Julia Tuulik, per BBC News. February 28, 2022 Emanuela Pecchia is famously known as the wife of popular Swiss-born Italian thoracic surgeon, Paolo Macchiarini. WebPaolo Macchiarini Net Worth. Paolo Macchiarini is exposed Reality struck Alexander's fantasy romance eight weeks before she was supposed to marry Macchiarini in 2015, when she received an email from a colleague with the subject line saying, "The Pope." Acquittal is therefore difficult to defend., But Gerdin says the verdict is not unexpected. Around the same time, an article in Vanity Fair described how Macchiarini had misled a girlfriendan NBC news producer working on a flattering documentary about his surgeriesinto thinking they would be married in a ceremony attended by the Clintons and Obamas and officiated by the pope. But in October 2017, the attorney general's office announced that a crime could not be proven, because the patients might have died anyway. Macchiarini told people that Barack and Michelle Obama, Bill and Hillary Clinton, Nicolas Sarkozy, and Vladimir Putin would attend the wedding, Andrea Bocelli would perform, and Pope Francis (a patient of his, or so he said) would officiate the ceremony, per Vanity Fair. The theory was simple: let the body do most of the work. An advantage is that immunosuppressants are necessary only for several months, he said. Even so, it wasnt until 2016 that the Karolinska Institute declined to renew his contract. That drama began about a decade ago when Dr. Paolo Macchiarini, working at Swedens famed Karolinska Institute, garnered headlines and accolades for replacing The tube was necessary because her trachea the airway leading to the lungs had become damaged after she spent weeks on a ventilator for a severe asthma attack in 2014. Benita was also growing increasingly concerned, because she had not yet been introduced to Paolo's children or even seen where she was meant to live with him in Barcelona. She received another implant at the University College Hospital in London in 2011, after which she was able to be discharged. In the first couple of years at Karolinska, he put plastic airways into three patients. Chief judge Bjoern Skaensberg said the court agreed that Macchiarinis operations were not consistent with science and proven experience, but the court determined that two of the interventions were justifiable.. Disgraced Italian surgeon convicted of criminal harm to stem cell patient. Most, including Andemariam Beyene, are now dead. Greys Anatomy Alum Isaiah Washington Retires from Acting, Tom Sizemore, Saving Private Ryan Star, Dies at 61, Chris Rock Live on Netflix, No Salvation on Last of Us, A World Without Bart Simpson, Kids Choice Awards, Rachael Ray Ending After 17 Seasons: Its Time for Me to Move On, Enver Gjokaj Returns as Captain Milius on NCIS: Hawaii, Copyright 2023 NTVB Media, Inc., All Rights Reserved, Stolen Youth: Inside the Cult at Sarah Lawrence, Luke Kirby, Ashley Madekwe & More Join Dr. I have to expose him.". None have been forced to hold full and independent inquiries. The charismatic Italian surgeon who designed it foresaw a future where hearts and lungs could be made from plastic, and organ donations became a thing of the past. Virginia Here are 13 more things about him: He married Pecchia in 1986. But, we now know that the success of this operation was a lie, and the complications she suffered because of it were kept under wraps for a really long time. 2023 Cinemaholic Inc. All rights reserved. Border crisis: Whats happening at the US-Mexico border? They allowed Macchiarini to continue his work as a visiting professor with a research lab. But it was already too late. From that moment on, she made a proposal to Paolo Macchiarini, and Dateline planned to publish the story. As per Castillo was soon back home, chasing after her kids. After being dismissed from the institute, he worked at the Kazan Federal University in Kazan, Russia. The procedure involved replacing a damaged trachea with a plastic replica that had been soaked in the patients stem cells. 2023 Guardian News & Media Limited or its affiliated companies. Its enough to worry officials from the US Food and Drug Administration (FDA). The first was a Vanity Fair article about his affair with Benita Alexander, an award-winning producer for NBC News. Get more great content like this delivered right to you! However, its imperative to mention that the doctor has only been criminally found guilty of causing bodily harm to a single patient he operated on in Sweden back in 2011 two other charges of assault were dismissed. The court had to apply the intentional indifference standard for the assault charges, he says, which is difficult to prove. KI fired Macchiarini in March 2016, 2 months after the Swedish documentary came out. Sadly, she passed away soon after her second implant. They will especially examine the judges decision that Macchiarini couldnt be held responsible for what happened to Andemariam and Lyles because he acted in distress, according to the courts statement. Apparently, her graft detached soon after, causing an infection, and because of difficulties in breathing, she had to be admitted into emergency a total of 13 times. The district court in Solna today found Paolo Macchiarini not guilty on other charges, including aggravated assault, relating to three patients he treated while working for the famed Karolinska Institute (KI). But after Alexander learned that Pope Francis was scheduled to visit South America at the time of their wedding, she confronted Macchiarini about his claims. Texas On Friday Mr. Hurtig declined to comment on Paolos private affairs.. As the home of the Nobel prize in physiology or medicine, one of its ambitions is to create scientific celebrities. Then, in October of 2009, another woman, who had been operated on by Paolo twice before, received her airway transplant. The university board was dismissed and even Harriet Wallberg, whod moved on to become the chancellor for all Swedish universities, lost her job. The coronavirus pandemic will most likely create more cases because many Covid-19 patients have needed weeks on ventilators. According to Macchiarini and his colleagues, her artificial organ was well on the way to looking and functioning liked a natural one. Macchiarini is known for his research fraud and manipulative behavior. 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The Vatican confirmed that he had never been the Pope's doctor. If the Pope was planning to marry two divorcees, surely it would be huge global news? So did Karolinskas dean of research. She remained conscious and awake throughout most of them, but unable to breathe. That was a very smart idea to help maintain the fragile blood supply of the airway by leaving the esophagus in place behind it, Dr. Patterson said. Most protagonists on medical dramas are modern-day heroes. However, Swedish TV reporters also decided to take a close look at Macchiarinis work. A High-Flying Italian Surgeons Fall From Grace, https://www.nytimes.com/2022/06/17/world/europe/macchiarini-windpipe-surgeon-deaths.html. Stem cell clinics have sprung up like weeds, offering to treat just about any ailment you can name. Macchiarinis argument that KI fully supported and encouraged the surgeries likely swayed the judges as well, he says. This organ was prepared without the knowledge of authorities in a veterinary lab at the University of Bristol, but no one questioned it because of its initial success. Subscribe to News from Science for full access to breaking news and analysis on research and science policy. Other trachea replacement attempts include transplanting part of a donors frozen, preserved aorta, the bodys main artery, and fabricating tracheas from patients own chest muscles and rib cartilage. There he reinvented his technique. Paolo Macchiarinis most notable patient is Claudia Castillo. What's next for abortion rights in America? A panel of judges unanimously ruled that the interventions were not in accordance with science and proven experience, according to a statement released today. WebIn reality, Paolo had not worked with the Pope, and he was still married to his wife of 30 years. Every patient had another, nonlethal option, Pierre Delaere, a trachea expert at KU Leuven and an early critic of Macchiarini, said in an email to Science. Turn on desktop notifications for breaking stories about interest? Gerdins report, released in May 2015, concluded Macchiarini was guilty of misconduct, but university administrators rejected that conclusion 3 months later, arguing Macchinarini and his co-authors had satisfactorily countered the issues Gerdin raised. The Karolinska University Hospital in Stockholm. Benita first met Paolo at the bar at Bostons Mandarin Oriental hotel in February 2013, when she was helping coordinate an interview for an NBC special on regenerative medicine. Thats what our experience of medical research leads us to suspect. In 2013, the hospital halted future operations with synthetic trachea and opted to not extend Macchiarinis contract. A genius is a revolutionary by definition, a risk-taker and a law-breaker. As of late March, 6.5 percent of cells in the donor trachea were hers, with the proportion increasing, he said. By this year, Dr. Genden said, her condition had deteriorated so that if we delay further, its not going to work out.. A version of this story appeared in Science, Vol 376, Issue 6600. As a subscriber, you have 10 gift articles to give each month. In 2017, Paolo worked at a university in Russia, where he was given a federal grant for oesophagus research on primates, and operated on baboons rather than humans. An independent investigator agreed. According to the judgment in Macchiarinis case, hospital staff said that Cetir had around 40 near-death experiences and was conscious but unable to breathe for many of them. The case is pending. Its love of human interest stories makes it sympathetic to unproven therapies. He could see no real evidence that the windpipe scaffolds were becoming living, functioning airways in which case, they were destined to fail. One of these is the hype surrounding stem cells. He hopes the immunosuppressant drugs, which can create health risks, can be reduced or even stopped if the entire graft becomes filled with Sonias cells.. After several weeks in recovery, she is home. If we've learned anything from the COVID-19 pandemic, it's that we cannot wait for a crisis to respond. They recently published an article in the New England Journal of Medicine admitting that stem cell research has mostly failed to live up to its therapeutic promise. After realizing other treatment methods wouldnt help, he concluded that Ms. Sein had a logical, thoughtful grasp of transplantations risks and of her health condition. This thing came to life, Dr. Genden marveled, and we were like, Holy smokes, weve done it.. In 2019, an Italian court said he had forged documents and abused his position, charges unrelated to his trachea work. Alexander admits that, at the time, she was in a vulnerable place. In such dire circumstances, new treatments can be tried as a last resort. 2023 American Association for the Advancement of Science. All rights reserved. Paolo Macchiarini, in a 2013 photo, implanted synthetic windpipes into multiple patients; all but one died following complications with the implants. Almost immediately after she was fitted with a synthetic trachea in August 2012, Ms. Cetirs condition began to rapidly deteriorate, according to the courts written judgment.