66(3): 463-473. 75:12128-12140. 5): S418-S422. Ebola binding to Tim-1 on T-Lymphocytes induces a cytokine storm. J. Virol. (2018) Therapeutic human monoclonal antibody MR191against Marburg virus targets a conserved site to block receptor binding. Dis. Several strategies have been developed in the past to treat EBOV infection, including the antibody cocktail ZMapp, which has been shown to be effective in nonhuman primate models of infection ¹ and has been us … The University of Texas Medical Branch at Galveston, Graduate Training in Experimental Pathology, Pathology Residency & Fellowship Program, Paul Brindley Distinguished Professorship, Pathology Microscope Imaging Core Laboratory, 2018 DMT Conference UTMB Faculty & Staff Registration. King, B. R. West, C. L. Moyer, P. Gilchuk, A. Flyak, P. A. Ilinykh, R. Bombardi, S. Hui, K. Huang, A. Bukreyev, J. E. Crowe, Jr. and E. Ollmann Saphire (2019). Immunization of primates with a Newcastle disease virus-vectored vaccine via the respiratory tract induces high titer serum neutralizing antibodies against highly pathogenic avian influenza virus. J. Infect. Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. A. Bukreyev, I. M. Belyakov, G. A. Neutralizing antibodies from human survivors target a conserved site in the ebolavirus glycoprotein HR2/MPER regions. 125(8): 3241-55. Our research includes experiments in a BSL-2 labs and in BSL-4 labs of the Galveston National Laboratory. 218 (Suppl. Development of therapeutics targeting filoviral replication and interferon-antagonist functions (in collaboration with Dr. Sergei Nekhai and Dr. Chris Basler). 1994. Sci. B. 162(8):2493-2504. Together they form a unique fingerprint. J. Virol. Cell Host & Microbe 23(1):101-109. 82 (24):12191-12204. P. A. Ilinykh, B. Tigabu, A. Ivanov, T. Ammosova,  Y. Obukhov, T. Garron, N. Kumari, D. Kovalskyy, M. O. Platonov, V. S. Naumchik,A. L. B. Characteristics of Filoviridae: Marburg and Ebola Viruses. The article was chosen for UTMB press releases on 12/01/2016. Role of TMEM16F in the incorporation phosphatidylserine into budding ebolavirus virions. Most UTMB Health clinics offer on site laboratory services to conveniently meet your health care needs at the point of service. A. Bukreyev and P. Collins (2008). J. DiNapoli, S. Samal, P. Collins, and A. Bukreyev (2010). Review. The secreted G protein of human respiratory syncytial virus (RSV) antagonizes antibody-mediated restriction of replication involving macrophages and complement. Multifunctional pan-ebolavirus antibodies recognize a site of broad vulnerability on the ebolavirus glycoprotein. S. Netesov, S. Wagener, A. Bukreyev, L. Kolombet, D. Pobedimskaya, R. Hawley, I. Belyakov, Y. Remnev, E. Turin (2010). Journal of Virology JVI01845-18R1 in press. J. Harker, A. Bukreyev, P. Collins, B. Wang, J. S. Tregoning, and P. J. M. Openshaw (2007). These topic labels come from the works of this person. *Co-corresponding author. However, if your physician has ordered a test to be performed in one of our clinical laboratories, please choose the location that best fits your needs from the options below. Dive into the research topics where Thomas Ksiazek is active. Ward, A. Bukreyev,* and J. E. Crowe, Jr. (2016) Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection. Ward. Non-commercial Partnership "Center of Modern Medical Technologies TEMPO". Irma Cisneros, PhD Director, Pathology Imaging Core Lab Email: ircisnero@utmb.edu Phone: (409) 772-3938. MCP M114.041129. K. A. Dave, E. L. Norris, A. 80:5854-5861. July 16, 2011. Crowe Jr. Turner, T. Alkutkar, R. Flinko, C. Orlandi, R. Carnahan, R. Nargi, R.G. Biol. A. Bukreyev, S. S. Whitehead, N. Bukreyeva, B. R. Murphy, and P. L. Collins (1999). Possibility and challenges of conversion of current virus species names to Linnaean Binomials. B. P. L. Collins and A. Bukreyev (2007). Geisbert, A.B. Nature Communications 10 (1):1788. (2010). ICTV, Viruses, in press. Future Medicine: Future Virology 2 (6):537-541. A. Harker, D. C. P. Lee, Y. Yamaguchi, B. Wang, A. Bukreyev, P. L. Collins, J. S. Tregoning, and P. J. M. Openshaw. Academic Press. A. I. Flyak, P. A. Ilinykh, C. D. Murin, T. Garron, X. Shen, M. L. Fusco, T. Hashiguchi, Z. (2017). Comparative immunology of bats as a reservoir of emerging viral infections. 77:9156-9172. 218 (Suppl. J. Virol. P. A. Ilinykh, X. Shen, A. I. Flyak, N. Kuzmina, T. G. Ksiazek, J. E. Crowe, Jr., and A. Bukreyev (2016) Chimeric filoviruses for identification and characterization of monoclonal antibodies. A. I. Flyak, N. Kuzmina, C. D. Murin, C. Bryan, E. Davidson, P. Gilchuk, C. P. Gulka, P. A. Ilinykh, X. Shen, P. Ramanathan, K. Huang, H. Turner, M. L. Fusco, R. Lampley, N. Kose, H. King, G. Sapparapu, B. J. Doranz, T. G. Ksiazek, D. W. Wright, E. Ollmann Saphire, A. J Biol. The article was chosen for UTMB and the Vanderbilt University press releases on 5/26/2015. P. A. Ilinykh, J. Graber, N. A. Kuzmina, K. Huang, T. G. Ksiazek, J. E. Crowe, Jr. and A. Bukreyev (2018). (2018). “This is a very important project that we hope will help us understand why bats maintain filoviruses as well as multiple other emerging viruses without getting ill” Bukreyev … USA. (2018). Gunn, A.L. 74:11017-11026. 352 (6289): aad7993. As a Clinical Laboratory Scientist, you become a behind-the-scenes detective in the health care industry, accurately and precisely performing laboratory procedures to provide crucial information in diagnosing, preventing, and treating diseases. J. Virol. Vaccine 29:17-25. Cell Reports 24: 1816-1829. Cell. A. Bukreyev, A. Marzi, F. Feldmann, L. Zhang, L. Yang, J. M. Ward, D. Dorward, R. J. Pickles, B. R. Murphy, H. Feldmann, and P. L. Collins (2009). Protein phosphatase-1-targeting small molecule C31 inhibits Ebola virus replication. The article was chosen for Icahn School of Medicine at Mount Sinai press releases on 4/28/2016. P. Younan, M. Iampietro, R. I. Santos, P. Ramanathan, V. L. Popov and A. Bukreyev (2018). Cell Host & Microbe 23(1):101-109. Dive into the research topics where Alexander Bukreyev is active. U. J Buchholz, A. Bukreyev, L. Yang, E. W. Lamirande, B. R. Murphy, K. Subbarao, and P. L Collins (2004). T. S. Postler, A. N. Clawson, G. K. Amarasinghe, C. F. Basler, S. Bavari, M. Benko, K. R. Blasdell, T. Briese, M. J. Buchmeier, A. Bukreyev et al. 5): S335-S345. Bachelor of Science in Clinical Laboratory Sciences. 90(15):7567-83. T. Ammosova, C. A. Pietzsch, Y. Saygideğer, A. Ilatovsky, X. Lin, A. Ivanov, N. Kumari, M. Jerebtsova, A. Kulkarni, M. Petukhov, A. Üren, A. Bukreyev* and Sergei Nekhai* (2018). J. Virol. mBio 9(5): e01771-18. The article was chosen for UTMB press releases on 05/24/2017. English-Russian Harmonized Dictionary of Biological Safety and Security. A. Bukreyev, P. E. Rollin, M. Tate, L. Yang, S. R. Zaki, W.-J. The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains. Ebolavirus chimerization for the development of a mouse model for screening of Bundibugyo-specific antibodies. L. Yang, A. Sanchez, P. E. Rollin, B. R. Murphy, P. L. Collins, and A. Bukreyev (2008). National Institute of Allergy and Infectious Diseases Staff Recognition Awards in Recognition and Appreciation of Special Achievement. J. Virol. Expression of immunomodulating molecules by recombinant viruses: Can the immunogenicity of live virus vaccines be improved? Review. Filoviridae: The Marburgviruses and Ebolaviruses. Impairment of the CD8+ T cell response in lungs following respiratory versus non-respiratory viral infections. H. Bisht, A. Roberts, L. Vogel, A. Bukreyev, P. Collins, B. Murphy, K. Subbarao, and B. Moss (2004). L. Zhang, A. Bukreyev, C. Thompson, B. Watson, M. E. Peeples, P. L Collins, and R. J. Pickles (2005). P. A. Ilinykh, R. I. Santos, B. M. Gunn, N. A. Kuzmina, X. Shen, K. Huang, P. Gilchuk, A. I. Flyak, P. Younan, G. Alter, J. E. Crowe, Jr., and A. Bukreyev (2018). N. M. Lubaki*, P. Younan*, R. I. Santos, M. Meyer, M. Iampietro, R. A. Koup, and A. Bukreyev. Natl. Natl. Review article. Nature Structural & Molecular Biology 26(3):204-212. P. Ilinykh, M. Lubaki, S. Widen, L. A. Renn, T. C. Theisen, N. R. Rabin, T. Wood, and A. Bukreyev (2015) Different temporal effects of Ebola virus VP35 and VP24 on global gene expression in human dendritic cells. Assymetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap. J. Infect. A. Bukreyev,  M. E. Serra, F. R. Laham, S. R. Kleeberger, P. L. Collins, and F. P. Polack (2006). The UTMB Department of Clinical Laboratory Sciences has the career path for you. The article was chosen for UTMB and the Vanderbilt University press releases on 5/26/2015. In 2017-2018, UTMB CLS graduates earned 100% ASCP Board of Certification one-year pass rate. Member of Global Viral Network, 2011-present. mBio 8(2) e00226-17. J. Infect. The article was chosen for UTMB press release and NIH press release on 7/13/2015. Turner, T. Alkutkar, R. Flinko, C. Orlandi, R. Carnahan, R. Nargi, R.G. J. Clin. Natl. J. Infect. Kirchdoerfer., K. M. Hastie, A. Sangha, J. Meiler, G. Alter, A. Bukreyev, J. E. Crowe, Jr., and E. Ollmann Saphire. A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication. 90(15):7567-83. Acad. , N. Kuzmina, C. D. Murin, C. Bryan, E. Davidson, P. Gilchuk, C. P. Gulka, P. A. Ilinykh, X. Shen, P. Ramanathan, K. Huang, H. Turner, M. L. Fusco, R. Lampley, N. Kose, H. King. The article was chosen for Lancet press release on 06/23/04 and the NIH press release on 06/24/04. B. (2018). M. Meyer, T. Garron, N. M. Lubaki, C. E. Mire, K. A. Fenton, C. Klages, G. G. Olinger, T. W. Geisbert, P. L. Collins, and A. Bukreyev. Bombardi, M.E. A. Bukreyev, L. Yang, B. Murphy, and P. Collins (2010). PLOS Pathogens 14(4):e1006932. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 and its targeting for the inhibition of viral transcription. A. Bukreyev and I. Belyakov (2002). Bombardi, M.E. A. Bukreyev, S. S. Whitehead, C. Prussin, B. R. Murphy and P. L. Collins (2000). Member of the Filoviridae Study Group of the International Committee on Taxonomy of Viruses, 2012-present. Mol. PLOS Pathogens 14(8):e1007204. Kirchdoerfer., K. M. Hastie, A. Sangha, J. Meiler, G. Alter, A. Bukreyev, J. E. Crowe, Jr., and E. Ollmann Saphire. Acad. Proc. State Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia. B. Infection of ciliated cells by parainfluenza virus type 3 in an vitro model of human airway epithelium. I. V. Kuzmin, T. M. Schwarz, P. A. Ilinykh, I. Jordan, T. G. Ksiazek, R. Sachidanandam, C. F. Basler, and A. Bukreyev (2017). Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Ilinykh, K. Huang, A. S. Wirchnianski, R. M. James, A. S. Herbert, S. Hui, E. Goodwin, K. A. Howell, S. Kailasan, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, K. Chandran and E. Ollmann Saphire (2019). J. M. DiNapoli, L. Yang, A. Suguitan Jr., S. Elankumaran, B. R. Murphy, S. K. Samal, P. L. Collins, and A. Bukreyev (2007). Interleukin 18 co-expression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. Overview. Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis. B. Dr. Soong’s research focuses on New World cutaneous, mucosal and visceral leishmaniasis. Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans. 84(10):5294-5302. Syst. J. DiNapoli, A. Kotelkin, L. Yang, B. R. Murphy, S. Samal, P. L. Collins, and A. Bukreyev (2007). Vaccine, 27 (10):1530-1539. Bestel online of kom langs in onze winkels. 70:6634-6641. J. Virol. J. Virol. J. Virol. Our collaborators include Dr. James Crowe, Jr. (Vanderbilt University), Dr. Chris Basler (Mount Sinai), Dr. Sergei Nekhai (Howard University), Dr. Thomas Geisbert (UTMB), Dr. Siba Samal (University of Maryland), Dr. Scott Weaver (UTMB), Dr. Raul Andino (UCSF), and Dr. Werner Braun (UTMB). mBio 8(5) e00845-17. The Master of Science degree in Clinical Laboratory Science (MSCLS) in the School of Health Professions is designed to prepare the clinical laboratory scientist for a career in research, teaching or management within clinical laboratory medicine. C. Le Nouën, P. Hillyer, S. Munir, C. C Winter, T. McCarty, A. Bukreyev, P. L Collins, R. L Rabin, and U. J Buchholz (2010). Expression of interleukin-4 by recombinant respiratory syncytial virus is associated with accelerated inflammation and a non-functional cytotoxic T lymphocyte response following primary infection but not following challenge with wild-type virus.

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