Licorice. https://naturalmedicines.therapeuticresearch.com. Modified-release nitrate preparations: use a once-daily dose to maintain a nitrate-low period and thus minimize tolerance. HHS Vulnerability Disclosure, Help Methods: Watch for any symptoms that you may be having a drug interaction, such as: Mayo Clinic does not endorse companies or products. Severe postural hypotension with light-headedness and dizziness is frequently observed after the consumption of alcohol. other information we have about you. Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. https://naturalmedicines.therapeuticresearch.com. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. Talk to your provider if you notice your chest pain starts to get worse. It is unknown if this medication passes into breast milk. Real test is coronary angiography. See also: nitroglycerin side effects in more detail. Isosorbide mononitrate dose 10 mg twice daily to 120 mg daily in divided doses. Do not drink alcohol while taking View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Talk to your doctor if you are using marijuana (cannabis). To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Let your provider know if you are using any medications for erectile dysfunction before you start taking isosorbide mononitrate (Monoket). 41% of reviewers reported a positive effect, while 50% reported a negative effect. the unsubscribe link in the e-mail. May also be prescribed off label for Esophageal Spasm. The IR version can help treat and prevent angina. Isosorbide-2,5-dinitrate and isosorbide-5-mononitrate, the low-potent organic nitrates, are directly metabolized in the endoplasmic reticulum of the vascular smooth muscle cells via cytochrome P450 enzymes, resulting in direct production of nitric oxide (Mnzel et al., 2005).In contrast, the highly potent organic nitrates such as glyceryl trinitrate (GTN) and pentaerythritile tetranitrate . Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. What You Need to Know, Angina (a specific type of chest pain) caused by heart disease. Profen and Metoclopramide drug interaction, Metoclopramide and Nitrostat drug interaction, Metoclopramide and Alfentanil drug interaction, Risperdal and Metoclopramide drug interaction. Isosorbide mononitrate (Monoket) is not a medication you take if you think you are having a heart attack. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. Do not let anyone else take your medication. This is a condition where the heart does not beat as efficiently as it should. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. official website and that any information you provide is encrypted Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat. Changing positions slowly can help lessen dizziness. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. https://naturalmedicines.therapeuticresearch.com. This content does not have an Arabic version. Alcohol can make the side effects from isosorbide worse. These relax smooth muscle within the blood vessels, widening them and making it easier for blood and oxygen to reach the heart Calcium antagonists (eg, diltiazem, nifedipine, nimodipine, verapamil). It is not intended as medical advice for individual conditions or treatment. All rights reserved. If headaches continue or become severe, tell your doctor promptly. Ask your doctor before using aspirin together with alcohol. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. In case of overdose, call the poison control helpline at 1-800-222-1222. Generic alternatives may be available. This is called tolerance, and it cannot be fixed by raising the dose of the medication. Normal ecg doesn't rule out heart disease. Does Alcohol Raise Your Blood Pressure? https://naturalmedicines.therapeuticresearch.com. 2017; doi:10.1016/j.jacc.2016.11.078. 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Many common herbal supplements interact with common heart medicines. Medicines containing Isosorbide Mononitrate. Moderately clinically significant. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Isosorbide mononitrate (Monoket) is available as a generic medication and may be significantly cheaper compared to the brand version. Talk to your provider if you continue to feel dizzy or have a fast heart rate a week after starting isosorbide mononitrate (Monoket). The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. Many herbal supplements can interact with prescription drugs. The two dosage regimens were equally efficient for the relief of angina pectoris without development of tolerance. Prescribed for Angina, Anal Fissure and It can cause your blood pressure to become dangerously low. Change positions slowly until your body is used to the medication. If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Do not take more or less of it or take it more often than prescribed by your doctor. It is best not to drink alcohol while you are on isosorbide mononitrate. Integrative medicine (complementary and alternative medicine). Truven Health does not assume any responsibility or risk for your use of the Truven Health products. To view a report comparing 3 (or more) medications, please sign in or create an account. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. You may report side effects to Health Canada at 1-866-234-2345. Medicines Complete BNF 84th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. If it is within 2 hours of the next dose, skip the missed dose. Consult your doctor before breast-feeding. Avoid combinations; the risk of the interaction outweighs the benefit. This is so your doctor can check on your progress. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. If we combine this information with your protected PMC National Library of Medicine Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. No you may not. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. But only about 25% of people who take herbal supplements tell their health care providers. https://naturalmedicines.therapeuticresearch.com. you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Mehta D. Herbal & dietary supplements. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. Mayo Clinic does not endorse companies or products. Higher dosages are associated with stomach irritation and If you notice any other effects, check with your healthcare professional. This survey is being conducted by the WebMD marketing sciences department. Isosorbide mononitrate belongs to the group of medicines called nitrates. Unless your doctor tells you otherwise, continue your normal diet. Some of these interactions can be life-threatening. Elantan, Imdur, Isotard, Monomax, Tardisc, Xismox. Zhonghua Yi Xue Za Zhi (Taipei). Unable to load your collection due to an error, Unable to load your delegates due to an error. Copyright, 2023. Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Tolerance is more likely to happen if you don't take your dose at the same time every day. B complex. Headache is often a sign that this medication is working. This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Do not share this medication with others. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Accessed Sept. 7, 2022. Mehta D. Botanical medicines. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.AvanafilRiociguatSildenafilTadalafilVardenafil. Otherwise, call a poison control center right away. Your doctor will probably tell you not to take isosorbide if you are taking one of these medications. Overview of herbal medicines and dietary supplements. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. 1998 Oct;61(10):577-83. A total of 195 drugs are known to interact with isosorbide mononitrate: A total of 330 drugs are known to interact with aspirin: A total of 239 drugs are known to interact with nitroglycerin: No known alcohol/food interactions. Headache and weakness of left side (both arm and leg) may suggest a brain pathology. Egton Medical Information Systems Limited. Saw palmetto. Natural Medicines. Try to keep your regular appointments with your doctor. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Using this medicine with any of the following medicines is not recommended. Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. Evening primrose. Canada residents can call a provincial poison control center. St. John's wort. In: Current Medical Diagnosis & Treatment 2022. Take them to your local pharmacy which will dispose of them for you. Always consult your healthcare provider. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Many people using this medication do not have serious side effects. Limit alcoholic beverages. Isosorbide dinitrate dose 30-120 mg daily in divided doses. 2005 - 2023 WebMD LLC. Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Dated August 2017. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Does isosorbide mononitrate (Monoket) lower blood pressure? People with kidney problems should be able to take the usual dose of isosorbide mononitrate (Monoket). The Swedish Multicentre Group. The extended-release capsule usually is taken once daily. Conclusions: Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your health care provider and pharmacist can help you stay away from unsafe interactions. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks ( chest pain ). May also be prescribed off label for Esophageal Spasm. http://www.upandaway.org. you should know that you may experience headaches every day during your treatment with isosorbide. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. . Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Swallow the tablet/capsule whole - do not chew or crush it before you swallow. Do not stop taking it without consulting your doctor. It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. Prices for isosorbide mononitrate (Monoket) start at just $29.86 with a GoodRx coupon. This medication may interfere with certain laboratory tests (including cholesterol levels), possibly causing false test results. It might help to take isosorbide mononitrate and dinitrate after meals. All rights reserved. Store in a cool, dry place, away from direct heat and light. The extended-release tablet usually is taken once daily in the morning. Daily headaches are a common side effect. Of the total drug interactions, Natural Medicines. What should I know regarding pregnancy, nursing and administering Isosorbide Mononitrate to children or the elderly? Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Some of these medicine interactions can be risky. Do not try to change the times or the way that you take isosorbide in order to avoid headaches because then the medication may not work as well. Isosorbide mononitrate (Monoket) can cause your blood pressure to drop somewhat. 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